Dr. Persano graduated in Pharmaceutical Biotechnology in 2005 at the University of Padova. Since his PhD studentship in Oncology and Surgical Oncology at University of Padova, Dr. Persano’s studies have been focused on dissecting the molecular pathways underlying cancer progression and resistance to therapy, with particular focus on the role played by tumour microenvironment. Indeed, in the Laboratory of Molecular Immunology and Gene Therapy directed by Dr. Indraccolo, in which he achieved his PhD in 2009, his project was committed to study the process of tumour angiogenesis and exploit its potential inhibition as a therapeutic strategy in different tumors including prostate, ovarian, esophageal and colon cancers. In 2009 Dr. Persano moved to the Laboratory of Pediatric Oncohematology directed by Prof. Basso, in which he focused his interests in brain tumour biology with particular emphasis in unveiling the mechanisms by which brain tumor microenvironment (i.e. hypoxia) influences the activation of many developmental pathways including Bone Morphogenetic Proteins, Wnt and Notch signalings. In this context, in the recent years the Brain Tumors Team developed a multilayer model of Glioblastoma in which they characterized the activation of the hypoxic signalling and its crosstalk with Glioblastoma cancer stem cells. Dr. Persano’s studies on Glioblastoma have been granted by the University of Padova (Young Investigator Grant 2010) for the development of a two-year project as independent PI with full scientific and financial responsibilities. In particular, the project was committed to the study of BMP2 as a reliable pro-differentiating molecule to induce glioblastoma cell differentiation. Moreover, from 2010 he is in charge for the coordination of the activities of the Brain Tumors Unit in the Laboratory of Pediatric Oncohematology, University of Padova, currently located at the Institute of Pediatric Research. Dr. Persano has recently obtained an IRP Consolidator Grant for studying the mechanisms of therapy resistance in medulloblastoma tumors.
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