I graduated in Medical Biology at the University of Padova (Italy) in 2008, after one year spent at the University of Wuerzburg (Germany) where my commitment to cancer research started. In 2012 I completed my PhD in Oncology and Surgery Oncology at the Department of Surgery, Oncology and Gastroenterology at the University of Padova where I studied the role of Notch3 signaling both in colorectal cancer and in leukemia. (Serafin V. et al, Journal of Pathology 2011, Pastò A. et al, Cancer Research 2014, Ghisi M. et al, Blood 2011). During my PhD I had the opportunity to collaborate with the Oncohaematology Laboratory headed by Prof. Basso where afterward I started my post doc under the supervision of Dr. Accordi. During this period I have been supported for three years by the Fondazione Italiana per la Ricerca sul Cancro (FIRC) and two years by the Fondazione Umberto Veronesi (FUV), and I published 13 scientific papers in peer-reviewed international journals regarding phosphoproteomic profiling of pediatric Acute Leukemias and other pediatric and not diseases. Among them, I initiated and developed a project regarding glucocorticoid resistance in pediatric patients affected by T Acute Lymphoblastic Leukemia (T-ALL). I observed an hyperactivation of LCK kinase in patients more resistant to glucocorticoids and in ETP T-ALL, a subset of patients highly resistant to therapy (Serafin V. et al, Blood 2017, Serafin V. et al, Leukemia 2017). These evidences have an important clinical relevance since this pathway can be pharmacologically inhibited to sensitize cells and turn patients responsive to the action of glucocorticoids. Focusing on the characterization of molecular mechanisms underlying the glucocorticoid resistance in 2019 I won the My First AIRC Grant, that allowed me to start my independent career as junior principal investigator at the Institute of Pediatric Research “Città della Speranza”. During this year I also had the opportunity to spend a short period of time at the Northwestern University in Chicago where I improved my molecular basic science competence in order to carry on this ambitious project. Now, I am building up my research group applying for founding to increase my autonomy as scientist and develop my own field of research.
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