News

News

Seminar: Epigenetic control of stemness in CD8+ T-cell fate commitment

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Seminar: Applications of Functional Genomics to Disease Gene Discovery: from “Known Unknowns” to “Known Knowns”

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Seminar: “Regulation and function of epigenetic modifications in stem cells” and “Microenvironmental interactions in chronic lymphocytic leukemia: moving up a NOTCH?”

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Journal Club

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Seminar: Novel insights into the biomechanics of leukocyte migration

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How can nanotechnology help the fight against breast cancer?

How can nanotechnology help the fight against breast cancer? Elisabetta Avitabile, Davide Bedognetti, Gianni Ciofani, Alberto Bianco and Lucia Gemma Delogu Nanoscale  
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How can nanotechnology help the fight against breast cancer?

How can nanotechnology help the fight against breast cancer? Elisabetta Avitabile, Davide Bedognetti, Gianni Ciofani, Alberto Bianco and Lucia Gemma Delogu Nanoscale
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BMP9 counteracts the tumorigenic and pro-angiogenic potential of glioblastoma

BMP9 counteracts the tumorigenic and pro-angiogenic potential of glioblastoma Elena Porcù, Francesca Maule, Daniele Boso, Elena Rampazzo, Vito Barbieri, Gaia Zuccolotto, Antonio Rosato, Chiara Frasson, Giampietro Viola, Allesandro Della Puppa, Giuseppe Basso, Luca Persano Official journal of the Cell Death Differentiation Association
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Somatic mutations in specific and connected sub-pathways are associated to short neuroblastoma patients’ survival and indicate proteins targetable at onset of disease

Somatic mutations in specific and connected sub-pathways are associated to short neuroblastoma patients’ survival and indicate proteins targetable at onset of disease Maria Rosaria Esposito, Andrea Binatti, Marcella Pantile, Alessandro Coppe, Katia Mazzocco, Luca Longo, Mario Capasso, Vito Alessandro Lasorsa, Roberto Luksch, Stefania Bortoluzzi, Gian Paolo Tonini International Journal of Cancer
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Could the interaction between LMX1B and PAX2 influence the severity of renal symptoms?

Could the interaction between LMX1B and PAX2 influence the severity of renal symptoms? Negrisolo S, Carraro A, Fregonese G, Benetti E, Schaefer F, Alberti M, Melchionda S, Fischetto R, Giordano M, Murer L European Society of Human Genetics 2018
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Addition of dose-intensified doxorubicin to standard chemotherapy for rhabdomyosarcoma (EpSSG RMS 2005): a multicentre, open-label, randomised controlled, phase 3 trial

Addition of dose-intensified doxorubicin to standard chemotherapy for rhabdomyosarcoma (EpSSG RMS 2005): a multicentre, open-label, randomised controlled, phase 3 trial Gianni Bisogno, Meriel Jenney, Christophe Bergeron, Soledad Gallego Melcón, Andrea Ferrari, Odile Oberlin, Modesto Carli, Michael Stevens, Anna Kelsey, Angela De Paoli, Mark N Gaze, Helene Martelli, Christine Devalck, Johannes H Merks, Myriam Ben-Arush, Heidi Glosli, Julia Chisholm, Daniel Orbach, Veronique Minard-Colin, Gian Luca De Salvo European paediatric Soft tissue sarcoma Study Group
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Dr Laura Rigon was awarded the “2° Premio Triennale Hic Labor 2017 – Catergoria Materie Scientifiche e Tecniche” prize

Dr Laura Rigon was awarded the “2° Premio Triennale Hic Labor 2017 – Catergoria Materie Scientifiche e Tecniche” prize

On June 23rd, Dr. Laura Rigon, a member of the laboratory “Diagnosis and Therapy of Lysosomal Disorders“, was awarded the “2° Premio Triennale Hic Labor 2017 – Catergoria Materie Scientifiche e Tecniche” prize for her PhD thesis entitled “Nanotechnologies for CNS drug delivery: therapy for the neurological compartment in the Mucopolisaccharidoses”. The research work was also supported by the Fondazione Cariparo in the framework of the Bando di Ricerca Pediatrica.
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Dr Bianca Calì presented “CXCL12/SDF-1 Modulates the Rheological Properties of the Nucleus of Mouse Neutrophils”

Dr Bianca Calì presented “CXCL12/SDF-1 Modulates the Rheological Properties of the Nucleus of Mouse Neutrophils”

Dr Bianca Calì, member of the Inflammation and Angiogenesis Lab directed by prof. Antonella Viola, presented an oral presentation entitled "CXCL12/SDF-1 Modulates the Rheological Properties of the Nucleus of Mouse Neutrophils" to the last “The Chemokine System at the Crossroads of Physiology and Disease” Gordon Conference (June 3 - 8, 2018 - Newry, ME, US) Read more: https://www.grc.org/chemotactic-cytokines-conference/2018/
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Dr Bianca Calì presented “CXCL12/SDF-1 Modulates the Rheological Properties of the Nucleus of Mouse Neutrophils”

Dr Bianca Calì presented “CXCL12/SDF-1 Modulates the Rheological Properties of the Nucleus of Mouse Neutrophils”

Dr Bianca Calì, member of the Inflammation and Angiogenesis Lab directed by prof. Antonella Viola, presented an oral presentation entitled "CXCL12/SDF-1 Modulates the Rheological Properties of the Nucleus of Mouse Neutrophils" to the last “The Chemokine System at the Crossroads of Physiology and Disease” Gordon Conference (June 3 - 8, 2018 - Newry, ME, US) Read more: https://www.grc.org/chemotactic-cytokines-conference/2018/
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Approved the 2017 financial statements

Approved the 2017 financial statements

Recruited new researchers, enhanced facilities, appointed the SAB, launched a website On Monday 25th June, the participating partner’s meeting of the Istituto di Ricerca Pediatrica Città della Speranza took place. The 2017 financial statements were approved. Andrea Camporese, CEO, reminded those present of the significant changes made to the statute last year, with the goal of becoming an international reference in its field. The technical board has introduced a new governance model composed of a managing director, a scientific director, a scientific committee and a scientific advisory board. "In addition, to ensure that the Institute is able to concentrate exclusively...
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A finite element analysis of diaphragmatic hernia repair on an animal model

A finite element analysis of diaphragmatic hernia repair on an animal model. N. de Cesare, C. Trevisan, E. Maghin, M. Piccoli, P.G. Pavan Journal of the Mechanical Behavior of Biomedical Materials
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Maintenance Chemotherapy Extends Life for Children With a Rare Cancer – First Treatment Advance for This Cancer in 30 Years

Maintenance Chemotherapy Extends Life for Children With a Rare Cancer – First Treatment Advance for This Cancer in 30 Years

CHICAGO – A new chemotherapy strategy improves cure rates for children with rhabdomyosarcoma (a rare cancer of the muscle tissue) who are at high risk for cancer recurrence. In a randomized phase III clinical trial, adding six months of low-dose maintenance chemotherapy after initial treatment increased the 5-year overall survival rate from 73.7% to 86.5%. Children with rhabdomyosarcoma who are alive at five years are considered cured, as tumor recurrence is very rare. These findings will be presented in ASCO’s Plenary Session, which features four studies deemed to have the greatest potential to impact patient care, out of the more than...
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Gli impatti del clima sulla nostra vita. Palazzi: “Rischi per l’approvvigionamento idrico”

Gli impatti del clima sulla nostra vita. Palazzi: “Rischi per l’approvvigionamento idrico”

Di cosa parliamo quando nominiamo i cambiamenti climatici? La ricercatrice Elisa Palazzi ha fissato l’attenzione su alcuni aspetti importanti - sette, ma potrebbero essere certamente di più – inerenti le nostre conoscenze sui mutamenti in corso e su quelli attesi, nonché sui loro impatti. Li svelerà mercoledì 30 maggio nella conferenza di chiusura del “Viaggio al centro della scienza”.   Dottoressa Palazzi, lei studia i cambiamenti climatici nelle regioni di montagna. Perché queste ultime sono le maggiori sentinelle di tale fenomeno? Perché rispondono più intensamente e più in fretta ai cambiamenti esterni. Se, globalmente, nell’ultimo secolo e mezzo circa, la...
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Decellularized Diaphragmatic Muscle Drives a Constructive Angiogenic Response In Vivo.

Decellularized Diaphragmatic Muscle Drives a Constructive Angiogenic Response In Vivo. Alvarèz Fallas ME, Piccoli M, Franzin C, Sgrò A, Dedja A, Urbani L, Bertin E, Trevisan C, Gamba P, Burns AJ, De Coppi P, Pozzobon M. Int J Mol Sci. 2018 Apr 28;19(5)
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Liposomal delivery of a Pin1 inhibitor complexed with cyclodextrins as new therapy for high-grade serous ovarian cancer

Liposomal delivery of a Pin1 inhibitor complexed with cyclodextrins as new therapy for high-grade serous ovarian cancer Concetta Russo Spena, Lucia De Stefano, Stefano Palazzolo, Barbara Salis, Carlotta Granchi, Filippo Minutolo, Tiziano Tuccinardi, Roberto Fratamico, Sara Crotti, Sara D'Aronco, Marco Agostini, Giuseppe Corona, Isabella Caligiuri, Vincenzo Canzonieri, Flavio Rizzolio Journal of Controlled Release 281 (2018) 1-10
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