The principal aim of our research is the identification of new disease biomarkers and new therapeutic targets for acute pediatric leukemias through phosphoproteomic profiling by Reverse Phase Protein Arrays (RPPA). We believe that monitoring the activation status of signal transduction pathways will be key to identify patient subgroups that can benefit from the use of specific kinase inhibitors and to point out proteins suitable for patients risk stratification and targeted therapy.
In recent years through RPPA we identified and then validated new potential biomarkers and therapeutic targets for B-ALL, T-ALL and AML pediatric patients. Moreover, we are also investigating the combined metabolic and signaling inhibition approach in pediatric T-ALL.
The Phosphoproteomics group is in charge of the RPPA facility management and is involved in several national and international collaborative studies focused on the phosphoproteomic profiling of different neoplastic and non neoplastic diseases.
- Valentina Serafin
Selected PublicationsSerafin V, Capuzzo G, Milani G, Minuzzo SA, Pinazza M, Bortolozzi R, Bresolin S, Porcù E, Frasson C, Indraccolo S, Basso G, Accordi B.. 2017. Glucocorticoid resistance is reverted by LCK inhibition in pediatric T-cell acute lymphoblastic leukemia.. Blood, 130(25):2750-2761
Serafin V, Lissandron V, Buldini B, Bresolin S, Paganin M, Grillo F, Andriano N, Palmi C, Cazzaniga G, Marmiroli S, Conter V, Basso G, Accordi B.. 2017. Phosphoproteomic analysis reveals hyperactivation of mTOR/STAT3 and LCK/Calcineurin axes in pediatric early T-cell precursor ALL. Leukemia, 31(4):1007-1011
Milani G, Rebora P, Accordi B, Galla L, Bresolin S, Cazzaniga G, Buldini B, Mura R, Ladogana S, Giraldi E, Conter V, Te Kronnie G, Valsecchi MG, Basso G.. 2014. Low PKCα expression within the MRD-HR stratum defines a new subgroup of childhood T-ALL with very poor outcome. Oncotarget, 5(14):5234-45
Accordi B, Galla L, Milani G, Curtarello M, Serafin V, Lissandron V, Viola G, te Kronnie G, De Maria R, Petricoin EF 3rd, Liotta LA, Indraccolo S, Basso G.. 2013. AMPK inhibition enhances apoptosis in MLL-rearranged pediatric B-acute lymphoblastic leukemia cells. Leukemia, 27(5):1019-27
Accordi B, Espina V, Giordan M, VanMeter A, Milani G, Galla L, Ruzzene M, Sciro M, Trentin L, De Maria R, te Kronnie G, Petricoin E, Liotta L, Basso G.. 2010. Functional protein network activation mapping reveals new potential molecular drug targets for poor prognosis pediatric BCP-ALL. PLoS One, 5(10):e13552
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