Postdoctoral position available from June 2021 at Institute of Pediatric Research (IRP)

The prospective Post-doc candidate will have the opportunity to collaborate within the project entitled “Advanced therapy medicinal products for the treatment of ocular defects in Ectrodactyly- Ectodermal Dysplasia-Clefting (EEC) syndrome” funded by the Italian Ministry of Health.

For EEC patients carrying the p.R279H mutation, we will develop and characterize fully therapeutically effective eye drops, containing the identified allele specific siRNA molecules.
Experiments carried out during the preclinical phases will be repeated using the siRNA-Eye Drop Formulations (sEDF) in order to demonstrate the stability and activity of the siRNA molecules and their ability to restore full thickness stratification and differentiation of the EEC epithelia in a 3D organotypic model. All the information gained will be used to fill in a DMTA (Italian acronym for Dossier for Advanced Therapy Medicinal Product) needed to apply for a gene therapy clinical study.

The ideal candidate should have the following qualifications:

  • a Master’s Degree in Biology/Biotechnology/Medical Sciences;
  • fluency in English;
  • technical proficiency in the following areas: cell and tissue culture, immunohistochemistry, microscopy (confocal is a great plus), molecular biology, biochemistry;

The position is available immediately for 3 years in the first instance, although continuation may be possible. Salary will be commensurate with skills and experience.

Interested candidates should send their CV, cover letter and contact information for professional references to:

Prof. Enzo Di Iorio | vincenzo.diiorio@unipd.it

Position available in the Experimental Cardiology laboratory at the Institute for Pediatric Research (IPR) Città della Speranza, Padova

We are seeking for a highly motivated fellow to join our team collaborating with clinicians on a project aimed at elucidating the molecular bases of left ventricular non-compaction (LVNC) and cardiac dysfunction in muscular dystrophy-associated cardiomyopathies. The project spans from in vitro work, employing patient iPSC-derived cardiomyocytes, to in vivo experiments, carried out in mouse models of LVNC and dystrophy. Applicants should have expertise in stem cell culture, molecular biology (CRISPR/Cas9 technology) and animal work. Prior experience with iPSCs reprogramming and cardiomyocyte differentiation will be considered a plus. Position is available immediately.

Lab research interests include characterization of mitochondrial sources of reactive oxygen species and modulation of mitochondrial function in relation to cardiac disease, as well as the interplay between ROS signaling and autophagy.

Interested candidates should send their CV, cover letter and contact information for professional references to:
Dr. Nina Kaludercic |
nina.kaludercic@unipd.it