After many years of basic biomedical research at laboratories in Europe, University of Amsterdam (NL) – University of Nijmegen (NL) – Queen Elisabeth Foundation Brussels (B) – University of Lund (SE) – University of Pavia (IT) – University of Padova (IT), and the US Dr. Geertruy te Kronnie now follows her main research interest ‘integrating genetics with cancer predisposition’. She teaches Medical Genetics at the Medical School of the University of Padova (IT) and provides genetic counseling for pediatric patients and families with leukemia and lymphoma predisposition.
Dr. te Kronnie published more than 120 papers in international peer reviewed scientific journal of which >25 during the last 3 years. The published studies report biomedical research of leukemia and lymphoma with a focus on high content transcriptome specificities mainly of somato-genetic leukemia subtypes.
The high degree of transcriptional diversity of leukemia subtypes became even more apparent with the identification of non-coding RNAs such as microRNAs, long noncoding RNAs and alternative splicing events. In addition, circular RNAs (circRNAs), transcripts usually generated by the joining of a ‘5 splice site with the 3’ splice site of an upstream intron, were recently recognized as important elements in cellular regulation. Since several years circRNA expression in hematopoietic cells has been explored in the lab and together with the group of Stefania Bortoluzzi (AIRC-IG) a 4-year research project started recently.
Dr. te Kronnie is group leader of the workgroup of COST-ACTION16223 that investigates ethical, legal and socio-economic implications of inherited cancer predisposition, in particular leukemia and lymphoma in pediatric patients in Europe and reviews the current tools that are used to recognize and documents inherited cancer predisposition.
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