Scopus ID: 11440257300
Dr Paganin graduated in Biological Science, then she did her PhD in Developmental Medicine and Programming Science, Hematology-Oncology and Immunology, at the University of Padua. At the Pediatric Oncohematology Laboratory at the University Hospital of Padua she was in charge of the antigen receptor-based molecular analysis Group for minimal residual disease detection focusing mainly on the earlier identification of relapsed patients with acute lymphoblastic leukemia who could benefit of alternative treatment. Later she worked as Post-doc at the Institute for Cancer Genetics, Columbia University of New York facing novel research lines and specialized on next-generation sequencing studies to identify genetic aberrations and mutations cooperating in the T-cell acute lymphoblastic leukemia development. She was involved in projects on molecular characterization of T-cell acute lymphoblastic granted by the University of Padova for the genomic profiling of T-cell acute leukemia lineage switched in acute myeloid leukemia. Moreover, she studied the prognostic value of new genetic biomarkers for risk stratification of patients for the future development of tailored therapy thanks to the participation to the ERA-NET on Translational Cancer Research project. She was granted as Young Researcher Award from Ministry of Health to study a new strategy for the detection of residual leukemia cells, where next-generation sequencing technology has been applied as a new diagnostic method for minimal residual disease analysis and to follow the different leukemia clones during treatment. Her interest in oncogenes, tumor suppressor moves to study new molecular aspect that cooperate in driving T-cell acute lymphoblastic leukemia and thanks to a collaboration in a PRIN project, from Ministry Education, University and Research, she is studying circRNA identification and characterization in T-ALL. Moreover, she participates to the development of additional projects (Progetto Cariparo, AIRC) in which she serves as a team member for the experience in the T-cell acute lymphoblastic leukemia field and in gene mutations analysis. Her scientific production counts 26 original papers published in peer-reviewed Journals (Scopus H-index = 13, 1043 total citations).