Our research team has 30 years of experience in translational medicine of acute lung diseases (including animal models, newborns, and adults) and in genetic mutations of lung surfactant-specific proteins.
The focus of our research is the development of stable isotope and mass spectrometry-based approaches to improve the understanding of human biology on a cellular and whole-organism levels.
Presently, we are working to identify clinically relevant markers of neurologic and pulmonary injuries in pediatric cardiac-surgery and their link to neurodevelopmental and respiratory deficits, as an “in vivo” model to study the effect of an acute injury on organ function (lungs, heart and brain) in neonatal, pediatric and adult intensive care. The role of lipid and protein metabolism in this setting by stable isotopes techniques will be part of this research work.
We recently described how the minimum temperature reached during children cardiac surgery is the most important factor that influences the rise of a brain injury neuromarker and how the type of cardiac diseases is linked to a specific pulmonary surfactant status. Moreover, we linked a specific marker of brain injury (GFAP), along with other surgical parameters, to children’s neurodevelopmental outcome at 18 months after surgery (Ann Thor Surgery in press 2018).
Studies on preterm and newborn infants’ nutrition (focused on parental nutrition) are also ongoing with important results obtained describing the metabolism of lipids components and their relationship with the diseases. Lipidomics studies are planned to study lipids metabolism in the fetus and during pregnancy.
Along with clinical studies, cellular and molecular studies are in progress to describe the cellular activity of drugs on various types of cells and diseases. Moreover, the healing effect of the amniotic membrane is under investigation with different human primary cells.
- Manuela Simonato
- Luca Vedovelli
- Sonia Giambelluca
Selected PubblicationsL. Vedovelli, M. Padalino, S. D'Aronco, G. Stellin, C. Ori, Carnielli VP, Simonato M, Cogo P.. 2017. Glial fibrillary acidic protein plasma levels are correlated with degree of hypothermia during cardiopulmonary bypass in congenital heart disease surgery.. Interact Cardiovasc Thorac Surg., 24(3):436-442
Lamonica G, Amigoni M, Vedovelli L, Zambelli V, Scanziani M, Bellani G, Grassi A, Simonato M, Carnielli VP, Cogo P.. 2014. Pulmonary surfactant synthesis after unilateral lung injury in mice. J Appl Physiol (1985), 116(2):210-5
Cogo P, Facco M, Simonato M, Verlato G, Rondina C, Baritussio A, Toffolo GM, Carnielli VP.. 2009. Dosing of porcine surfactant: effect on kinetics and gas exchange in respiratory distress syndrome. Pediatrics, 124(5):e950-7
Carnielli VP, Simonato M, Verlato G, Luijendijk I, De Curtis M, Sauer PJJ, Cogo P.. 2007. Synthesis of long-chain polyunsaturated fatty acids in preterm newborns fed formula with long-chain polyunsaturated fatty acids. Am J Clin Nutr., 86(5):1323-30
Cogo P, Gucciardi A, Traldi U, Hilkert AW, Verlato G, Carnielli V. 2005. Measurement of pulmonary surfactant disaturated-phosphatidylcholine synthesis in human infants using deuterium incorporation from body water. J Mass Spectrom, 40(7):876-81
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